![]() ![]() Latasa and Cosgaya 2011 ), we focused on their regulation of RARb. RARb is a major mediator of RA (Ballow et al. RARb expression, abundance, and localization by RA or Dex treatment As RARb was the most affected RA receptor by RA or Dex (Fig. Two target proteins were also chosen to investigate neuronal plasticity. Indeed, for instance, the expression of RARb is RA-dependent through a positive feedback loop (Ballow et al. The receptors involved were investigated: RAR, RXR, GR, and MR. ![]() All three retinoids were also able to regulate to a similar extent both genes in purified primary Schwann cell cultures (Fig.ī), although TTNPB was more potent, specially regarding RAR-b up-regulation, indicative of its higher affinity for RAR binding compared to the natural retinoids 32.Īt the low concentration of 1 nM, TTNPB already produced a statistically significant down-regulation of RXR-c and upregulation of RAR-b, while 9-cis-RA or all-trans-RA only. Q Tip Amplified 320 Rar Code Essential ComponentsĬite Download full-text Contexts in source publication Context 1.Īll three retinoids were equally able to induce RAR-b and down-regulate RXR-c mRNA levels to a similar extent, which indicates that binding to RAR is sufficient to mediate the effect of retinoic acid (Fig.Ī).
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